Granulocytosis Syndrome (2)	

Neoplasms that are associated with the granulocytosis syndrome are found in the lung, oesophagus, stomach and pancreas. These patients always present with remarkable granulocytosis (greater than 20,000µl), fever refractory to antibiotics (greater than 38¡C) and hepatomegaly.
In most cases this syndrome, associated with lung cancer, develops at a rather early stage of the disease compared with other ectopic humoral syndromes. Postoperatively, following successful tumour resection, fever and hepatomegaly disappear acutely, and granulocytosis disappears more gradually. The differential diagnosis in these patients includes the possibility of a leukaemoid reaction that is induced by overt infection, or of coexistent chronic myelogenous leukaemia.